Turnaround leaders’ shifting gears in chronos and kairos time

Shifting gears to control drug-resistant tuberculosis.

TO THE EDITOR—How does the global community gain more traction in an effort to combat multidrug-resistant (MDR) tuberculosis globally? We have considered whether it would be helpful to address MDR tuberculosis as a separate epidemic. We introduced the idea because the dominant strategy globally for the past 2 decades has been based on the premise that MDR tuberculosis could be controlled by str...

Road Ecology: Shifting Gears Toward Evolutionary Perspectives

Recent advances in understanding the often rapid pace of evolution are reshaping our view of organisms and their capacity to cope with environmental change. Though evolutionary perspectives have gained traction in many fields of conservation, road ecology is not among them. This is surprising because roads are pervasive landscape features that generate intense natural selection. The biological ...

Shifting gears: Coping flexibility in children with and without ADHD

Nuclear Transport: Shifting Gears in Fungal Nuclear and Cytoplasmic Organization

In fungi, nuclear pore complexes are free to move through the nuclear envelope; however, little is known about how movement is regulated. New evidence reveals roles for molecular motors and potential impacts on genomic organization.

Shifting replication between IInd, IIIrd, and IVth gears.

W e used to think cells could get by with just a few DNA polymerases. One processive polymerase in Escherichia coli [polymerase III (Pol III)] was needed to make the long trip around the genome, and another one (Pol I) was needed to replace Okazaki fragment primers or damaged nucleotides. This view changed radically after 2 seminal studies by Nelson, Lawrence, and Hinkle (1, 2) in which 2 yeast...